Vardenafil, marketed and most known under the brand name of Levitra, is an oral drug intended for restoring erectile capacity in males. Before taking the drug, please carefully study the following instruction provided by the official website of Medsafe (New Zealand).
Vardenafil mechanism of action
Thanks to its mild and yet effective action, Vardenafil is a go-to solution for risk group patients: men aged above 65, patients with compromised kidney or liver function and heart problems, etc. Vardenafil is a first line defense drug against ED as a diabetes comorbidity (read more on correlation between the two conditions and management of ED in diabetic patients here).
Vardenafil is one of the five inhibitors of phosphodiesterase type 5 (PDE5) – an enzyme found in the smooth muscles of the penis and responsible for termination of erection. In men with ED, inhibition of the enzyme promotes release of nitric oxide and thus stimulates relaxation of smooth muscle fibers in the erectile bodies (the corpora cavernosa and corpus spongiosum). The relaxation of smooth muscles is achieved thanks to powerful vasodilatory action of Vardenafil. With the blood vessel walls rendered elastic, maximal blood absorption is achieved, and erection is exactly that: absorption and retention of blood within the erectile bodies of the penis.
Vardenafil dose titration and user recommendations
Vardenafil dose is to be appointed by a doctor at all times. They will proceed indicating the correct dose based on a sum of miscellaneous factors, such as how badly your erectile function is compromised, how well you tolerate the drug, what your body response towards the effect of Vardenafil is, whether or not you have any other health issues, etc. A physical examination, and in certain cases, blood panel works are required for the right dose to be established. Available Vardenafil doses are 5 mg, 10 mg or 20 mg, where Vardenafil 10 mg is the average commonly prescribed dose that can be lowered or increased based on patient response.
Vardenafil is taken on demand, before planned sexual activity; a time gap of ca 60 minutes should be allowed in between for the onset of the drug’s effects. Take a pill with ½-1 glass of water with or without food; fatty meals will inhibit and delay Vardenafil effects, and so will alcohol. But a light meal taken before Vardenafil ingestion is known to minimize the risk of side effects.
Vardenafil adverse events
The adverse events triggered by the use of Vardenafil are few, short-lived and mild in their nature, as a common rule. They are:
- Facial flushing
- Upset stomach
- Nasal congestion or discharge
- Altered color perception
- Drop in blood pressure
Severe Vardenafil effects are extremely rare; they require medical emergency:
- Loss of vision in one or both eyes
- Allergic reactions (rash, cough, difficulty breathing)
- Swelling of the lips, tongue or face
Vardenafil is regularly quoted as the safest solution against ED. The drug is taken as needed prior to sexual action. Vardenafil restores sexual ability for the period of time that lasts for 4-6 hours. Vardenafil online is available for sale as the brand drug under the name of Levitra or a significantly cheaper generic with fully analogous action and identical composition.