Sildenafil is used to treat symptoms of erectile dysfunction (ED) in male patients. Having been patented for the use in ED in 1998, the drug has a long history of safe use by this time and day. In New Zealand, as of recently a pill of Sildenafil can be bought without a GP prescription.
Sildenafil mechanism of action
The description of sildenafil citrate and the mechanism of its action should commence with mentioning that this substance is a potent vasodilator agent. By stimulating production of nitric oxide (NO) in the smooth muscles of the penis, sildenafil dilates the blood vessels found in the corpora cavernosa of male sexual organ. Maximal absorption of blood then follows, and thus a controllable and stable erection is achieved.
Erections achieved in a Sildenafil-medicated state subside in a natural way. Registered instances of priapism (abnormally lasting and / or painful erections) are very few. The effects of Sildenafil last during 4 to 6 hours. During this time one can achieve a firm and stable erection every time when sufficient sexual stimulation occurs, but only within the limits of one’s sexual temperament.
Sildenafil dose titration and user recommendations
To produce a meaningful effect, a pill of Sildenafil is supposed to be taken as needed, which is 40 to 60 minutes before you envisage your sexual activity. Do not crush the pill in your mouth or chew on it; a tablet of Sildenafil is supposed to be swallowed whole.
Taking Sildenafil after a light meal with help you avoid undesirable and adverse events associated with the drug intake. However, if taken after a heavy or fatty meal, Sildenafil will have some of its effects delayed and / or inhibited.
Alcohol should be used with extreme caution when taking Sildenafil tablets. Alcohol inhibits the action of the drug’s active substance and promotes a drop in blood pressure, much as Sildenafil itself, therefore a combination of the two potent vasodilators is highly not recommended.
A dose of 50 mg is considered to be universally applicable. However, in patients older than 60, as well as in those with compromised renal or hepatic function, Sildenafil clearance is slower, which means that higher concentration of the drug in plasma is achieved with loser doses (25 mg). If found ineffective, these doses can then be stepped up to Sildenafil 50 mg or 100 mg. Always follow recommendations of your prescriber when taking Sildenafil. Do not exceed one recommended dose. Dosing frequency is 1 tablet during 24 hours.
Sildenafil adverse events
Side effects of Sildenafil are mostly transient and mild; they tend to go away altogether with continued use. If adverse events caused by Sildenafil persist or become bothersome, seek advice of your prescriber.
What side effects to expect when taking Sildenafil:
- Facial flushing
- Diarrhea / upset stomach / indigestion
- Muscle pain
- Stuffy / runny nose
- Altered color perception
Seek medical help urgently if the following occur:
- Increased heart rate
- Facial swelling
- Pain in the arm or chest
- Skin rash
- Difficulty breathing
- Erection that lasts more than 4 hours or is painful
Sildenafil is a generic version of the famous Viagra with proven efficacy and safety. The pill is intended for the use in males for symptomatic treatment of ED with effects lasting during mean time period of 4 hours. Sexual stimulation is required for the drug to act. Side effects are well studied and transient in their nature. Full information on the drug can be accessed through the official New Zealand Ministry of Health website.