Brand Cialis

What is it used for?

Cialis (tadalafil citrate) is a drug taken prior to sexual activity in order to retrieve the ability to achieve and maintain erection of penetrative hardness. Cialis remains active during 36 hours after the intake, ensuring man’s ability to react with erection to every instance of sexual stimulation, with minimal refraction periods in between the sexual acts.

Cialis contains tadalafil citrate, and by ordering this drug from our pharmacy, you confirm that you are familiar with what tadalafil is, what its correct doses are, and how to take it without risks for your health. We recommend receiving medical advice before you commence your tadalafil therapy. It is important to seek medical help in case you develop side effects that are long-lasting or bothersome.

Drug mechanism of action

Tadalafil contained in Cialis is a vasoactive agent that blocks phosphodiesterase type 5 (PDE5), thus releasing nitric oxide (NO). The release of NO prevents the conversion of cyclic guanosine monophosphate (cGMP) to guanosine triphosphate (GTP). The build-up of cGMP has a vasodilating effect on the blood vessels found in the two corpora cavernosa and the corpus spongiosum, the erectile bodies in the penis, and this directs the blood flow to the genitals. The erectile bodies get filled with blood every time the brain sends the signal to the penile tissues to release cGMP with the molecules of NO.

In order for Cialis to start producing its health effects, the user has to be subjected to sexual stimulation. Tadalafil does not give any spontaneous erections. After ejaculation, the penis returns to its relaxed state.

Instructions for use and choosing the dose

Cialis comes in several doses. It is up to your prescriber to establish which dose you should begin your therapy with and continue with. The increase in dose should only be made if the expected results are not achieved with the current dose.

Dose Recommendations
Tadalafil 2.5mg Daily use for full ED recovery
Tadalafil 5mg Daily use for full ED recovery
Tadalafil 10mg Recommended initial dose
Tadalafil 20mg Maximal recommended dose

 

Cialis and other drugs

Cialis is a vasoactive drug metabolized by CYP3A4 enzyme, and most of its drug interactions are conditioned by these characteristics of the drug. Thus, Cialis should not be used in combination with medications from the following drug classes:

  • antihypertensives
  • antiretrovirals
  • antifungals
  • other drugs from PDE5 inhibitor class

See the full list of Cialis contraindications here.

Cautious use

Cialis should be used with caution in patients with decreased clearance rate, compromised liver function and in older patients with mild renal or hepatic problems. Cialis cannot be used in case of severe kidney or liver insufficiency. If your doctor admonishes you against any strenuous activity, including sexual activity, you should not take Cialis.

Cialis should not be taken with grapefruit or freshly squeezed grapefruit juice. Excessive use of alcohol can increase the risk of hypotensive crisis.

Contraindications for use

Cialis should not be used in individuals with the following conditions:

  • problems with heart or recent stroke
  • ulcerative disease of stomach or duodenum
  • degenerative disease of the eye retina or NAION
  • problems with blood tension
  • scarring, angulation or deformity of the penis
  • priapism (long or painful erections in the medical history)
  • sensitivity towards tadalafil, lactose or other excipients in Cialis
  • vascular diseases

Adverse reactions

Some patients taking Cialis may experience side effects of tadalafil, although as a common rule, the drug is well tolerated. These side effects are:

  • Back pain
  • Headache
  • Runny / stuffy nose
  • Hives
  • Stomach upset
  • Diarrhea
  • Nausea

Some side effects of Cialis are not as mild as the ones described above. The symptoms from the list below require attention from healthcare specialists immediately:

  • increased heart rate
  • difficulty breathing
  • swelling of the face, mucous of the mouth
  • vomiting
  • migraine
  • syncope
  • angina
  • pain in the arm

Overdose

The signs of tadalafil overdose will most commonly mimic those of severe side effects. You should report them immediately to your prescriber or to ER. Never take more than one dose prescribed to you by your GP or another healthcare provider in order to avoid tadalafil overdose effects.

Missed dose

You cannot miss a dose of Cialis as long as you are taking it as needed. In case you have missed a dose of Cialis Daily, take one as soon as you remember to. Never double-dose to make up for the missed dose of the drug.

Storage

The drug should be stored at room temperature away from children and pets; keep the drug in a place that is dry.

Toxicity

Cialis can build up toxicity if taken in doses exceeding 20mg within24 hours. If this happens, report to the nearest poison control center or ER. The symptoms will include those described under Side Effects section, but will be more intense in their nature.