Avana

What is it used for?

Avana (avanafil) is an orally administered erectogenic drug. Avana is taken prior to a sexual activity with a response window of 20 to 40 minutes and the therapeutic window of 4 to 5 hours. The drug helps men with inability or a compromised ability to achieve and maintain erection sufficient for a satisfactory sexual intercourse to achieve and maintain penile hardness.

Avana is a drug with the active substance avanafil. By ordering Avana from our website you confirm that you have received a medical consultation and were approved for the use of the drug; you also affirm that you received the instructions for safe use of Avana and are aware of possible side effects of the drug. We recommend seeking medical help in case of persistent or bothersome adverse events.

Drug mechanism and characteristics

Avana contains avanafil, which is a vasoactive inhibitor of phosphodiesterase type 5 (PDE5) that inhibits the degradation of cyclic guanosine monophosphate (cGMP) to guanosine triphosphate (GTP). Avana promotes the release of nitric oxide, a substance that activates the enzyme called guanylate cyclase, the precursor of cGMP.

The build-up of cGMP resulting from PDE5 inhibition and the release of NO helps the walls of the corpora cavernosal blood vessels relax, expand and absorb the maximal amount of blood. Since PDE5 is mainly found in the erectile bodies of the penis, this is where the smooth muscle relaxation occurs, allowing for blood absorption and hard controllable erections to occur every time in the presence of sexual arousal.

Doses and method

Avana should be taken before the planned sexual activity. The effects will only occur when there is sufficient sexual stimulation. It takes between 20 and 40 minutes for the drug effect onset to take place, with the peak concentration in plasma reached after 30-45 minutes. The duration of Avana effects (half-life elimination) is 4-5 hours.

Avana is available in the doses of avanafil 50mg, avanafil 100mg and avanafil 200mg. The substance features the highest safety profile among the drugs of its class, which allows taking it in larger doses for the optimal health outcomes. However, the individual doses should always be appointed by a licensed healthcare provider.

The general guidelines is that the initial dose is Avana 50mg or 100mg, to be adjusted based on the tolerance and response displayed by the patient.

Take a pill of Avana by mouth following with ½ to full glass of water. Avana can be taken in between or alongside with meals.

Use with caution

  • In patients with reduced creatinine clearance, the use of Avana should be cautious with possible reduction of the dose.
  • The drug should not be used if you cannot engage in any strenuous physical activity because of a heart condition.
  • Do not take Viagra with more than 3 units of alcohol, grapefruit or grapefruit juice.

Drug contraindications

Avana use is contraindicated in individuals with the following conditions:

  • high or low blood pressure
  • eye diseases like retinitis pigmentosa, NAION, glaucoma
  • ulcer of stomach or duodenum
  • Peyronie’s disease or priapism
  • heart disease
  • recently experienced stroke
  • hemorrhages
  • sensitivity towards PDE5 inhibitors or lactose
  • sickle cell anemia, leukemia, multiple myeloma

Possible drug interactions

Avana is not supposed to be taken concomitantly with drugs that can exacerbate its hypotensive potential:

  • antimycotic drugs
  • certain antibiotics
  • antiretroviral drugs
  • drugs against angina
  • antihypertensive drugs
  • finasteride
  • anticonvulsant drugs
  • other ED drugs

Eventual side effects

The side effects of Avana are rare, mild and transient. They are:

  • headache
  • flushing
  • rhinitis
  • indigestion
  • nausea
  • rash
  • vision disturbance
  • ringing in the ears

Severe Avana side effects occur in extremely rare cases and require immediate reporting to ER:

  • pain in the chest or arm
  • facial swelling
  • irregular heartbeat
  • loss of consciousness
  • confusion
  • obstructed airways
  • loss of vision

Overdose

Always follow the instructions given by your prescriber or found in the drug’s insert when using Avana in order to avoid overdosing on avanafil. The symptoms indicating overdose will most often be those from the list of severe side effects or intensified regular adverse events. Report to the nearest healthcare office in the event of Avana overdose.

Missed dose

The rules of missed dose do not apply to drugs taken on demand. Take a pill of Avana as soon as you remember to and wait for the effects to occur.

Storage

Store the package containing Avana tablets in a cool dry place unreachable for minors and pets.

Toxicity

The toxic levels of avanafil in blood plasma can be reached when the dosing or other drug safety rules are neglected. If this occurs, consult your prescriber or any other healthcare provider available immediately.